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Our Publication List:
Production of Novel Antiprotozoal and Anthelminthic Compounds from Marine Surface Associated Bacteria,
Sala Uddin GM1, 2*, Md. Rashed Nejum2, Md. Rezuanul Islam2 and Md. Monirul Islam3,4
Journal of Marine Science: Research & Development 9 (1), 1-6, 2019 (Impact factor:1.62)
Abstract
Parasitic infections are the most prevalent in humans in developing countries and one third of the world population are infected by intestinal parasites.[read more] In addition, it affects millions of heads of livestock throughout the world. Global infections and widespread drug resistances exhibited by both protozoa and helminthes which have great challenge to present medicine. New medicine or bioactive may be talented solution of this problem. Combinatorial biosynthesis is one of the approaches for protecting parasitic infection but bioactive from natural origin provides diversity and structural complexity of the compounds with densely packed functional groups allowing maximum selectivity and interaction to the target. Currently the majority of antibiotics used in clinical practice are natural product origin. Living marine surfaces provide environment rich epibiotic microorganisms (e.g., bacteria) that produce bioactive compounds. By improving the culturability and using upgrade techniques it is possible to overcome the challenge of bioactive production. Microorganisms are currently accepted as the best renewable source of bioactive and marine living surface have great potential of producing novel bioactive compounds useful for further drug development. This review evaluate that marine surface associated bacteria are great source for production of novel antiprotozoal and anthelminthic compounds.[/read]
Exploring the Attitudes, Beliefs and Perceptions of Undergraduate and Graduate Students in Bangladesh towards Precision Medicine and Pharmacogenomics Practice: A Qualitative Study
European Journal of Medical and Health Sciences, 5(2), 22-34, 2023 factor:1.62)2.
Abstract
The aim of this study is to investigate the attitude, beliefs, and perceptions among undergraduate and graduate students toward precession medicine (PM) and pharmacogenomics (PGx) practice.[read more] A cross-sectional survey is conducted amongst students from different universities in Bangladesh.The results of the survey showed that the majority of students had a positive attitude towards precision medicine and pharmacogenomics, perceiving it as a means to improve diagnosis and treatment accuracy. Furthermore, many students also expressed a willingness to learn more about precision medicine and pharmacogenomics, suggesting that there is potential for these practices to be utilized in Bangladesh. Particularly in this study, 337 students from life science and relevant programs participated. From this study, it is shown that 84% of graduate students and 74% of undergraduate students thought PM is a promising healthcare model. In addition, 39% of students are highly encouraged to pursue their post-graduation in the subject areas of PGx and PM to support patients. The majority (62%) thought that patient privacy was the ethical concern most closely related to pharmacogenomic testing, while 19% of respondents thought that data confidentiality was the key issue. The results provide insight into the potential of precision medicine and pharmacogenomics in Bangladesh and suggest that further research into the attitudes of healthcare professionals should be conducted in order to take full advantage of the potential of these practices.[/read]
Molecular Epidemiology of HCV RNA Genotype-3 in Dhaka City, Bangladesh
Sala Uddin GM1, 2*, Md. Rashed Nejum2, Md. Rezuanul Islam2 and Md. Monirul Islam3,4
Journal of Marine Science: Research & Development 9 (1), 1-6, 2019 (Impact factor:1.62)
Abstract
Hepatitis C virus (HCV) is a causative agent that causes chronic liver diseases worldwide. It is a little, enclosed, single-stranded ribonucleic acid (RNA) virus.[read more] The recognition of the pathogenic HCV genotype is critical for the remedy of its sufferers. The aim of this study was to identify the HCV RNA genotype to decide the correct treatment of hepatitis C positive sufferers in Bangladesh. Blood samples were collected from 390 individuals and isolated RNA (60 µg) from blood plasma. Extracted RNA was used for quantitative HCV RNA, and complementary DNA (cDNA) was prepared by polymerase chain reaction (PCR) conducted by reverse transcriptase enzyme. This cDNA amplified in multiplex by RT-PCR, which was performed with specific set of primers. The HCV RNA genotype was detected 297 of 390 patients. Of the 390 test samples, 200 (51.28%) samples were from males and 190 (48.71%) were from females, with age ranging from 5 to 78 years. In all, 166 of 200 male samples and 131/190 female samples were found positive for HCV. Of these 390 participants included in the study, 213 (54.61%) were identified as genotype 3 positive, 78 (20%) as genotype 1 positive, 6 (1.53%) as genotype 6 positive, and the remaining 93 (23.85%) samples were unclassified due to low/undetected viral load. In this study, we detected the highest percentage (30.89%) of genotype 3 HCV in patients aged 51 to 60 years. The results suggested that genotype 3 HCV is frequently present in Bangladesh and it is usually responses better to interferon therapy. However, genotype 1 and 6 HCV have also been found circulating in this country, which demands longer treatments and effective control measures. [/read]
- Production of Novel Antiprotozoal and Anthelminthic Compounds from Marine Surface Associated Bacteria,
Sala Uddin GM1, 2*, Md. Rashed Nejum2, Md. Rezuanul Islam2 and Md. Monirul Islam3,4
Journal of Marine Science: Research & Development 9 (1), 1-6, 2019 (Impact factor:1.62)
Abstract
In general, genetic testing can help patients with hereditary disorders make crucial decisions related to prevention, treatment, and early detection. However, insufficient awareness about its significance is a contributing factor to the rising incidence of such disorders. [read more]To address this issue, the current study objects to investigate the level of know-ledge, awareness and attitudes towards genetic testing among undergraduate and graduate students in Bangladesh. A total of 408 participants from different universities were surveyed, and the data was collected through a 38-question online survey that was divided into four sections. Among the participants, a large percentage of respondents were between 18 and 26 years old, with 59.8% holding a bachelor’s degree and 78.9% came from science-related fields. Most respondents had heard of genetic testing and know that it could be used to diagnose inherited disease. A large portion of the respondents indicated their readiness to undergo genetic testing, showing a clear preference for these tests to be carried out exclusively in hospitals under the guidance of doctors. The consensus among most participants was that genetic testing holds significant importance and should be recommended for all newborns and expectant mothers. However, there were some concerns about potential negative implications but overall attitudes towards genetic testing were positive with variations based on age, education, and fields of study. This study necessitates the implementation of educational programs that eliminate any misconceptions and help educate the public to minimize misunderstandings about genetic testing. The findings of this research provide valuable information about the possible application of genetic testing for inherited conditions in Bangladesh.[/read]